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We refer to this protein as Apollo and report that Apollo has the ability to localize to telomeres through an interaction with the shelterin component TRF2. Although its low abundance at telomeres indicates that Apollo is not a core component of shelterin, Apollo knockdown with RNAi Local lonely moms from st Cook Nebraska in senescence and the activation of a DNA-damage al at telomeres as evidenced by telomere-dysfunction-induced foci TIFs. The TIFs occurred primarily in S phase, suggesting that Apollo contributes to a processing step associated with the replication of chromosome ends. Furthermore, some of the metaphase chromosomes showed two telomeric als at single-chromatid ends, suggesting an aberrant telomere structure.

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Data were fitted using a multi-trait model and consisted of growth traits birth weight and weights at , , and days of age and carcass traits longissimus muscle area lma , back-fat thickness bf , and rump fat thickness rf , registered over 21 years in extensive breeding systems of polled nellore cattle in brazil.

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